Five-Year Survival 10 to 15 percent Investigational • Adjuvant chemotherapy must still be considered investigational, but several studies have shown a modest increase in disease-free survival and overall survival. • Treatment with radiation or chemotherapy or both before surgery has been used on an investigational basis in patients with Stage IIIA disease. Preliminary results suggest that there may be benefit by combining all three treatments in selected cases. Newer trials are giving cisplatin with etoposide , vinca alkaloids or other agents together with radiation, followed by surgery.